Drag to rotate · Scroll to zoom
Drag to rotate · Scroll to zoom
All data independently validated by SGS Proderm, Schenefeld, Germany
02 — The Problem
Molecular damage is structural failure
Hair is an engineered material. Each fiber is built from keratin protein chains arranged in coiled-coil structures, bundled into intermediate filaments, and crosslinked by disulfide bonds — one of the strongest bond types in biological materials.
Chemical treatments — bleaching, coloring, perming — break these disulfide bonds at the cortex level, which constitutes 90% of the hair's volume. Free thiol (-SH) groups are left exposed. The internal architecture weakens progressively.
This is structural failure, not cosmetic damage. And it requires structural solutions.
03 — DISULFIDE BONDS
The architecture of strong hair
Disulfide bonds are covalent S-S linkages between cysteine residues in adjacent keratin chains. They perform three critical structural functions.
Tensile Strength
Resistance to breakage under physical stress. Disulfide crosslinks distribute mechanical load across the keratin matrix.
Elastic Modulus
The ability to flex and return to shape. Crosslinks provide restoring force — higher density means greater flexibility retention.
Structural Integrity
Overall fiber cohesion and porosity resistance. The 3D crosslinked network maintains the cortex as a continuous structural unit.
04 — Bond Breakage
What happens when bonds break
Chemical treatments cleave disulfide bonds via oxidation or reduction reactions, generating free thiol (-SH) groups on each separated cysteine residue. The consequences are measurable and progressive:
Reduced Tensile Strength
Fewer crosslinks mean less resistance to mechanical stress.
Increased E-Modulus
The fiber becomes stiffer and less elastic — it snaps rather than bending.
Higher Porosity
Loss of structural cohesion opens gaps, accelerating moisture loss.
Damage Cascade
Each broken bond increases vulnerability of neighboring bonds.
05 — THE LANDSCAPE
Why traditional approaches fall short
Three generations of hair repair technology have each advanced the conversation — but none create new covalent bonds within the cortex with independently verified efficiency.
Legacy Bond Repaid
2014 — Gen 1: Re-linking
Small molecules crosslink free thiols via Michael addition. Contested mechanism — Di Foggia et al. (2021) found no cortex-level disulfide increase via Raman spectroscopy. Competing patents describe electrostatic bonds requiring weekly reapplication. Debated durability. No independent proof of cortex activity.
Peptide-based treatment
2020 — Gen 2: Peptide Filling
Biomimetic peptides designed to integrate into damaged keratin. No peer-reviewed human efficacy trials published. Large molecules with variable cortex penetration. Fills voids rather than creating structural crosslinks.
NextGen Molecular Reconstruction
2024 — Gen 3: Molecular Reconstruction
New covalent bond creation via Nobel Prize-validated click chemistry. Independent laboratory measurement by SGS Proderm. Cortex-level structural rebuilding. Patented molecules. Non-petroleum-synthesized. ANATOMY® — Click Chemistry · Independent Validation · Granted Patents.
06 — The Breakthrough
Click chemistry — Nobel Prize, 2022
Click chemistry describes a class of reactions defined by modularity, wide scope, very high yields, inoffensive byproducts, and stereospecificity.
The Nobel Committee stated these reactions "brought chemistry into the era of functionalism." ANATOMY applies thiol-ene and thiol-yne reactions — formally classified as click reactions — to create new covalent bonds within damaged hair.
Unlike approaches that attempt to re-link original disulfide (S-S) bonds, ANATOMY creates entirely new carbon-sulfur (C-S) covalent bonds, forming structural bridges between damaged keratin chains.
◆
2022 Nobel Prize in Chemistry
Carolyn Bertozzi · Morten Meldal · K. Barry Sharpless
Modular
Simple building blocks combine predictably to form complex structures.
Very High Yields
Near-complete conversion under mild conditions. 81.5% bis-adduct formation rate measured.
Mild Conditions
No harsh initiators, extreme pH, or elevated temperatures required.
Stereospecific
Reactions produce defined structural geometries — architectural precision at molecular scale.
07 — THE CHEMISTRY
Thiol recombination explained
Thiol-Ene Reaction
A free thiol group (-SH) adds across a carbon-carbon double bond (C=C), creating a new carbon-sulfur covalent bond — a thioether linkage. High yield, high rate, near-complete conversion under mild conditions. Each reaction creates one new C-S structural bridge.
Thiol-Yne Reaction
A free thiol adds across a carbon-carbon triple bond (C≡C). Each triple bond reacts sequentially with two thiol groups — doubling crosslinking density. Higher crosslinking density per reactive site → more interconnected structural networks.
Key Distinction
The result is not restoration of original S-S bonds. ANATOMY creates entirely new C-S covalent bonds — engineered for superior stability, flexibility, and permanence compared to the original biological linkages.
08 — MECHANISM OF ACTION
Four steps to molecular reconstruction
01 — Penetrate
Molecules optimized for cortex-level penetration via leave-in format. Sustained diffusion time allows migration past cuticle into the structural core.
02 — Target
Molecules find free thiol groups (-SH) on cysteine residues — the chemical signatures of broken disulfide bonds — with high specificity.
03 — React
Thiol-ene and thiol-yne click reactions proceed under mild conditions, forming stable carbon-sulfur (C-S) covalent bonds at each reactive site.
04 — Reconstruct
Bifunctional molecules bridge between separated keratin chains, creating 3D crosslinked networks that restore structural architecture.
09 — THE DATA
Measured. Not claimed.
All performance data independently measured by SGS Proderm (Schenefeld, Germany) on bleached human hair fiber samples under controlled laboratory conditions.
Tensile Strength Increase (15.2 → 35.8 cN)
E-Modulus Reduction (~3× greater than competitor)
Bis-Adduct Formation Rate
Granted Patents (not pending)
10 — THE MOLECULES
Patented molecular architecture
Three proprietary molecules — two with granted patents — designed for targeted cortex-level reconstruction. All non-petroleum-synthesized.
Aminalyl-S — Patent Granted
Patented crosslinking salt (Salt 4, Tb-0016). Rebuilds disulfide bond architecture, restoring strength and flexibility. Demonstrated measurable E-Modulus reduction in SGS Proderm testing.
Example title
Use this section to explain a set of product features, to link to a series of pages, or to answer common questions about your products.
Pro-Amino-X — Patent Granted
Patented crosslinking salt (Salt 2, Tb-0017). Repairs internal bonds and creates protective structural networks. Reduces brittleness within the cortex.
Oligopropate — In Development
Designed for deep cortex-level repair, targeting structural damage in the innermost regions of the hair fiber. Next-generation molecule expanding the ANATOMY molecular library.
11 — Independent Validation
Claims without published data are just marketing
ANATOMY's performance data is independently measured by SGS Proderm — Germany's leading cosmetic contract research organization.
SGS Proderm operates approximately 140 specialized researchers in Schenefeld, Germany, conducting efficacy and safety testing under German regulatory frameworks. They are part of SGS — the world's largest testing, inspection, and certification company with over 96,000 employees globally.
SGS Proderm has no financial interest in ANATOMY's results. They test. They measure. They report. This stands in contrast to the industry norm of proprietary in-house testing behind opaque "clinically proven" marketing claims.
12 — The Format
Why leave-in format is a mechanistic requirement
The leave-in format is not a product preference. It is a direct consequence of the reaction mechanism.
Thiol-ene and thiol-yne reactions require sustained contact time for active molecules to migrate past the cuticle and reach the cortex — where 90% of the structural damage exists.
Rinse-off products limit contact time to minutes. Most active material remains at the cuticle surface and is washed away before cortex penetration can occur.
13 — SAFETY & BIOCOMPATIBILITY
Engineered for biological compatibility
Mild Conditions
Click reactions proceed without harsh initiators, extreme pH, or elevated temperatures. The chemistry works within the normal conditions of hair and scalp biology.
Biologically Inert Bonds
The thioether linkages (C-S bonds) created are chemically stable and biologically inert — structurally analogous to natural keratin bonds but engineered for enhanced permanence.
Inoffensive Byproducts
Click chemistry by definition produces no harmful byproducts. The reaction efficiency (81.5% bis-adduct rate) means minimal unreacted material and maximum structural contribution.
14 — The Future
This is not the end of bond repair
It is the beginning of molecular reconstruction.
ANATOMY is a platform, not a product. Our molecular library continues to expand. Precision targeting. Next-generation delivery systems. Technologies currently in development that will define the next decade of structural hair science.
Molecular Library
Expanding portfolio of patented crosslinking molecules, each targeting specific structural damage profiles.
Precision Targeting
Next-generation delivery systems designed for site-specific cortex repair based on individual damage mapping.
In Development
Technologies that will move molecular reconstruction from treatment to prevention. The science continues.
ANATOMY®
Explore the molecular reconstruction system
Two patented formulas. Nobel Prize-validated chemistry. Independently measured results. This is what structural hair science looks like.
All claims independently validated by SGS Proderm, Schenefeld, Germany